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Title   한국인에서 신세포암종발생과 CYP2D6 및 CYP1A1 의 유전적 다형성간의 관련성 ( Correlation between Genetic Polymorphism of CYP2D6 and CYP1A1 and Susceptibility of Renal Cell Carcinoma in Korean )
Publicationinfo   2000 Jan; 032(04): 801-810.
Key_word   Renal cell carcinoma, CYP2D6, CYP1A1, Genetic polymorphism
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Abstract   Purpose: Many of the enzymes handling environmental factors are polymorphic and may confer variable susceptibility to renal cell carcinoma (RCC). Among those, the author studied genetic polymorphisms of CYP2D6 (B & T) and CYP1A1 in RCCs and controls in Korean. Materials and Methods: Using 132 RCCs and 94 controls, first PCR products were obtained in 104 RCCs and 94 controls with CYP2D6, and 74 RCCs and 56 controls with CYP1A1. Restriction enzyme - BstN I/EcoN I for CYP2D6 (B & T), and NCo I for CYP1A1-digestion was followed to analyze constitutive DNA. Results: In both RCCs and controls, no mutant allele of CYP2D6 (B & T) was detected and the susceptibility for occurrence of RCC was unable to evaluate. With CYP1A1 RFLP, homozygous wild type (WW) was seen in 68 (52.3%; 37 RCCs, 31 controls), heterozygous mutant type (WM) in 54 (41.5%; 32 RCCs, 22 controls) and homozygous mutant type (MM) in 8 (6.2%; 5 RCCs, 3 controls). The odds ratios (95% CI) of RCC susceptibility for CYPIA1 genotype were 1.15 for WM and 1.36 for MM. Even though not significant statistically, higher tendency in MM presented. Conclusion: There is no association between susceptibility for the occurrence of RCC and genetic polymorphism of CYP2D6 (B & T) and CYP1A1
저 자   박규옥(Kyu Wook Park),정세일(Se Il Jung),정경우(Gyung Woo Jung),권헌영(Heon Young Kwon),정진숙(Jin Sook Jeong),전진호(Jin Ho Chun),윤진한(Jin Ho Chun)